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| Tyler Perry | Dr. Alex Cross | |
| Matthew Fox | Picasso | |
| Rachel Nichols | Monica Ashe | |
| Giancarlo Esposito | Daramus Holiday | |
| Jean Reno | Leon Mercier | |
| Edward Burns | Tommy Kane | |
| John C. McGinley | Richard Brookwell | |
| Carmen Ejogo | Maria Cross | |
| Tim Holmes | Referee | |
| Chad Lindberg | Vincent Dardis | |
| Cicely Tyson | Nana Mama | |
| Stephanie Jacobsen | Fan Yau | |
| Yara Shahidi | Janelle Cross | |
| Jessalyn Wanlim | Paramita Megawati | |
| Sayeed Shahidi | Damon Cross | |
| Werner Daehn | Erich Nunemacher | |
| Bonnie Bentley | Detective Jody Klebanoff |
| Director |
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| Producer | James Patterson
Randall Emmett |
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| Writer | James Patterson
Marc Moss |
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| Cinematography | Ricardo Della Rosa
Ricardo Della |
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| Musician | John Debney
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After Washington DC detective Alex Cross is told that a family member has been murdered, he vows to track down the killer. He soon discovers that she was not his first victim and that things are not what they seem. |
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